Li Yang
,
Liu Xuqiang
,
Tan Lili
,
Ren Ling
,
Wan Peng
,
Hao Yongqiang
,
Qu Xinhua
,
Yang Ke
,
Dai Kerong
材料科学技术（英）
doi:10.1016/j.jmst.2016.07.013
Implant-associated infection remains a difficult medical problem in orthopedic surgery. Therefore, the development of multifunctional bone implants for treating infection and regenerating lost bone tissue, which may be a result of infection, is important. In the present study, we report the fabrication of enoxacin-loaded poly (lactic-co-glycolic acid) (PLGA) coating on porous magnesium scaffold (Enox-PLGA-Mg) which combine the favorable properties of magnesium, the antibacterial property and the effect of inhibition of osteoclastic bone resorption of enoxacin. The drug loaded PLGA coating of Mg scaffold enables higher drug loading efficiency (52%-56%) than non-coating enoxacin loaded Mg scaffold (Enox-Mg) (4%-5%). Enox-PLGA-Mg exhibits sustained drug release for more than 14 days, and this controlled release of enoxacin significantly inhibits bacterial adhesion and prevented biofilm formation by Staphylococcus epidermidis (ATCC35984) and Staphylococcus aureus (ATCC25923). Biocompatibility tests with Balb/c mouse embryo fibroblasts (Balb/c 3T3 cells) indicate that PLGA-Mg has better biocompatibility than Mg. Finally, we also demonstrate that Enox-PLGA-Mg extract potently inhibited osteoclast formation in vitro. Therefore, Enox-PLGA-Mg has the potential to be used as a multifunctional controlled drug delivery system bone scaffolds to prevent and/or treat orthopedic peri-implant infections.
关键词:
Porous magnesium scaffold
,
Poly (lactic-co-glycolic acid) (PLGA)
,
Drug delivery system
,
Bactericidal activity
,
Enoxacin
,
Osteolysis
Jin Shujing
,
Ren Ling
,
Yang Ke
材料科学技术（英）
doi:10.1016/j.jmst.2016.06.022
Although being an essential trace element required for human body health, Cu has long been seriously considered toxic when its amount exceeds certain limitation, which significantly limited the wide application of Cu in biomaterials. However, more and more bio-functions and benefits of Cu were found and confirmed, attracting the attention from biomaterials researchers in recent years. People have tried to immobilize Cu into biomaterials by various ways, in order to develop novel bio-functional Cu containing biomaterials with better bio-adaptions, and several different bio-functions of them have been demonstrated. This paper makes a review of the development of novel bio-functional Cu containing biomaterials, and focuses on their unique roles in enhancing bio-adaption of biomedical materials, including antibacterial performance, stimulating angiogenesis, promoting osteogenesis and inhibition of in-stent restenosis, aiming at proposing a prospective development direction for biomedical materials with better bio-adaptions.
关键词:
Biomaterials
,
Cu
,
Antibacterial
,
Angiogenesis
,
Osteogenesis
,
In-stent restenosis
张麦仓
,
董建新
,
曾燕屏
,
谢锡善
,
罗子健
金属学报
利用热力耦合有限元程序FORMT,对PM René 95合金中等尺寸(外径尺寸约为630 mm)涡轮盘的等温锻造工艺进行了模拟式设计.结果表明,采用TZM钼基合金模具,在1050℃以接近10-3s.的应变速率进行闭式模锻和开式模锻,模具材料均能满足使用要求,且开式模锻设备最大载荷不超过31×103kN;采用K21合金模具,在1000℃以相同条件等温成形,模具材料因变形热效应及边界摩擦引起温升而失效且所需设备吨位相对较大.
关键词:
PM
,
null
,
null
,
null
张麦仓
,
董建新
,
曾燕屏
,
谢锡善
,
罗子健
金属学报
doi:10.3321/j.issn:0412-1961.2002.10.022
利用热力耦合有限元程序FORMT,对PM René 95合金中等尺寸(外径尺寸约为630 mm)涡轮盘的等温锻造工艺进行了模拟式设计.结果表明,采用TZM钼基合金模具,在1050℃以接近10-3s.的应变速率进行闭式模锻和开式模锻,模具材料均能满足使用要求,且开式模锻设备最大载荷不超过31×103kN;采用K21合金模具,在1000℃以相同条件等温成形,模具材料因变形热效应及边界摩擦引起温升而失效且所需设备吨位相对较大.
关键词:
PM René 95合金,等温锻造,热力耦合有限元,模拟式工艺设计
付锐
,
陈希春
,
任昊
,
冯涤
航空材料学报
doi:10.3969/j.issn.1005-5053.2011.3.002
自行设计开发了适合工业化生产高纯净,低偏析,无宏观缺陷铸锭的电渣重熔连续定向凝固技术(ESR-CDS)的设备和工艺,利用该技术成功制备了直径为φ150mm的René88DT合金定向凝周铸锭.采用XRD测试了定向凝固柱状晶的生长取向,结果表明,ESR-CDS René88DT铸锭柱状晶择优生长方向为<100>系晶向;ERS-CDS铸锭与传统ESR铸锭相比,枝晶组织生长方向保持一致,二次枝晶臂均匀细小,元素偏析程度低,且晶间一次析出相呈颗粒状,尺寸细小;等温热压缩实验结果表明,ESR-CDS René88DT合金热压缩试样在1100℃,0.0-50.1s-1应变速率下可达到70%以上压缩变形量并获得均匀细小的动态再结晶组织;ESR-CDS René88DT合金铸锭经等温锻造制备出了φ170mm×73mm的饼坯件,锻压变形量超过70%,饼坯件除上下两端的变形死区外均发生了动态再结晶,晶粒尺寸约50μm.
关键词:
电渣重熔连续定向凝固
,
热变形
,
动态再结晶
李晓
,
董建新
,
张丽娜
,
张麦仓
,
胡尧和
,
谢锡善
,
国为民
金属学报
经不同固溶时效处理的PM René 95合金于650℃分别在蠕变、保载5和90 s疲劳载荷条件下进行了裂纹扩展速率实验.结果表明,相同热处理制度下,疲劳保载时间越长,裂纹扩展速率越高;相同载荷条件下,增加一次高温固溶并缓冷,有利于降低合金的裂纹扩展速率,且固溶温度越高裂纹扩展速率越低;1200℃一次固溶缓冷并于1160℃二次固溶热处理比1140℃一次固溶的裂纹扩展速率约降低一个数量级;基体晶粒尺寸适当加大,强化相粒子γ′c数量增加、形状趋于田字形,有利于降低裂纹扩展速率.
关键词:
René
,
null
,
null
李晓
,
董建新
,
张丽娜
,
张麦仓
,
胡尧和
,
谢锡善
,
国为民
金属学报
doi:10.3321/j.issn:0412-1961.2001.10.012
经不同固溶时效处理的PM René 95合金于650℃分别在蠕变、保载5和90 s疲劳载荷条件下进行了裂纹扩展速率实验.结果表明,相同热处理制度下,疲劳保载时间越长,裂纹扩展速率越高;相同载荷条件下,增加一次高温固溶并缓冷,有利于降低合金的裂纹扩展速率,且固溶温度越高裂纹扩展速率越低;1200℃一次固溶缓冷并于1160℃二次固溶热处理比1140℃一次固溶的裂纹扩展速率约降低一个数量级;基体晶粒尺寸适当加大,强化相粒子γ′c数量增加、形状趋于田字形,有利于降低裂纹扩展速率.
关键词:
René 95粉末高温合金,裂纹扩展速率,热处理
MAO Weimin University of Science and Technology
,
Beijing
,
100083
,
China.
材料科学技术（英）
The recrystallization texture in commercially pure Al is investigated after the samples are rolled differently and annealed.The samples with low rol- ling reductions could be generally recovered or recrystallized in situ and characterized by the re- tained G{110}<001>component.This recovery process decreases during annealing with the increase of reduction.The appearance of the B/R{359}. <132>and R{123}<634>components de- pending on the rolling reduction is investigated and the less developed Cube{100}<001>component in commercially pure ahninium is also discussed.
关键词:
recrystallization
,
null
,
null
,
null
